Genetic studies of IgA nephropathy.

Clinical, Histopathological and Immunofluorescent Findings of IgA Nephropathy

Background: IgA nephropathy, a prevalent disease in Asia, is considered the main cause of end stage renal disease among primary glomerular disease. Objective: To determine the frequency of different clinical, histopathological and immunofluorescent characteristics of IgA nephropathy. Methods: Renal biopsies of 376 patients were received for immunofluorescent and for histopathological studies. B...

Genetics of immunoglobulin A nephropathy.

INTRODUCTION Immunoglobulin (Ig) A nephropathy is the most common primary glomerulonephritis in the world and about 20% to 50% of patients with it develop progressive renal failure. There is considerable evidence to show that IgA nephropathy is influenced by genetic factors. The purpose of this review is to provide useful information concerning genetics of IgA nephropathy. METHODS AND RESULTS...

Pathogenesis of IgA nephropathy.

Immunoglobulin A (IgA) nephropathy is an immune-complex-mediated glomerulonephritis characterized by the presence of immunoglobulin A deposits in mesangial and paramesangial regions. The patients with IgA nephropathy present with varying clinical symptoms (eg, microhematuria with preserved renal function or progressive deterioration of renal functions resulting in end-stage renal disease). The ...

Comment on: Clinical, Histopathological and Immunofluorescent Findings of IgA Nephropathy

IgA Nephropathy and Significance of Immunostaining Data

شیوع نفروپاتی IgA در بیماران مبتلا به گلومرولونفریت اولیه

During a 14-month period (Dec. 1990-Jan. 1992) , renal biopsies were performed on 105 patients with suspected glomerular disease. All specimens were processed for light microscopy (L.M) and immunoflourescence. Work-up revealed 21 patients to suffer a systemic glomerular disease and glomerular disease was found to be primery in 85 cases. Predominant IgG deposition was noted in 71 cases with prim...